EC50 (nM) | ||
Agonist | cAMP inhibition | Receptor internalization |
Ga-DOTATOC | 0.02 ± 0.01 | 11.0 ± 0.8 |
Cu-DA-TOC | 0.08 ± 0.07 | 78.3 ± 37.7 |
Cu-DA(IR800)-TOC | 1.38 ± 0.54 | 455 ± 299 |
Cu-MMC(IR800)-TOC | 0.21 ± 0.18 | 41.9 ± 29.8 |
Data are expressed as mean ± SD of the maximum possible effect for the agonist (Emax) values, which were calculated as difference between maximum and minimum signal for each analog and expressed as percentage of Emax value for internal control, Ga-DOTATOC.