In Vitro Profiles of TASP699, TASP0434299, and Candidate Metabolites of TASP699
| 3H-AVP binding | |||||
| Compound/peptide | Human V1B receptor | Human V1A receptor | Human V2 receptor | 3H-oxytocin binding, human oxytocin receptor | [Ca2+]i assay, human V1B receptor |
| TASP699 | 0.165 | >10,000 | >10,000 | >10,000 | 0.381 |
| Metabolite candidate 1 | >1,000 | — | — | — | — |
| Metabolite candidate 2 | 1.87 | — | — | — | — |
| TASP0434299 | 0.526 | >10,000 | >10,000 | >10,000 | 0.639 |
| AVP | 0.776 | 0.440 | 1.24 | — | — |
| Oxytocin | — | — | — | 0.731 | — |
— = not determined.
IC50 values (nM) are expressed as geometric means (n = 3–6).