Diagnostic Performance of 68Ga-DOTATATE PET/CT and CE-MRI for Detection of Osseous Involvement in Intracranial Meningiomas
| Method | Sensitivity | Specificity | Positive LR | Negative LR | Prevalence |
| Overall (n = 82) | |||||
| PET/CT | 98.5 (92.0–99.9) | 86.7 (60.0–98.3) | 7.39 (2.03–26.9) | 0.02 (0.00–0.12) | 81.7 (71.6–89.4) |
| CE-MRI | 53.7 (41.1–66.0) | 93.3 (68.1–99.8) | 8.06 (1.20–54.2) | 0.50 (0.37–0.66) | 81.7 (71.6–89.4) |
| Preoperative (n = 39) | |||||
| PET/CT | 100 (88.4–100) | 77.8 (40.0–97.2) | 4.50 (1.33–15.3) | 0.00 (NA) | 76.9 (60.7–88.9) |
| CE-MRI | 53.3 (34.3–71.7) | 100 (66.4–100) | ∞ (NA) | 0.47 (0.32–0.68) | 76.9 (60.7–88.9) |
| Postoperative (n = 43) | |||||
| PET/CT | 97.3 (85.8–99.9) | 100 (54.1–100) | ∞ (NA) | 0.03 (0.00–0.19) | 86.0 (72.1–94.7) |
| CE-MRI | 54.1 (36.9–70.5) | 83.3 (35.9–99.6) | 3.24 (0.53–19.9) | 0.55 (0.33–0.91) | 86.0 (72.1–94.7) |
LR = likelihood ratio; NA = not applicable.
Data are percentages (or ratios) followed by 95% confidence interval. Imaging diagnosis of “consistent with” was set as test-positive. McNemar test showed significant differences in diagnostic performance of PET/CT and CE-MRI (P < 0.001).