TABLE 4

Lesion-, Region-, and Subject-Level 18F-Fluciclovine PET/CT Interreader Agreement

ReaderRegionNAgreement (%)κ
1 vs. 2Lesion*6,54496.40.59† (0.55–0.64)
Prostate12191.70.67† (0.48–0.85)
Extraprostatic12181.80.64† (0.50–0.77)
Subject12193.40.57 (0.33–0.81)
1 vs. 3Lesion*6,58695.90.5 (0.45–0.55)
Prostate12177.70.43† (0.27–0.58)
Extraprostatic12176.00.56 (0.45–0.68)
Subject12177.70.28 (0.12–0.44)
2 vs. 3Lesion*6,87196.80.55† (0.50–0.60)
Prostate12179.30.49 (0.33–0.64)
Extraprostatic12174.40.53 (0.41–0.65)
Subject12179.30.37 (0.20–0.54)
All 3Lesion*6,49694.70.54†‡ (0.53–0.56)
Prostate12174.40.50‡ (0.40–0.59)
Extraprostatic12170.30.57‡ (0.48–0.66)
Subject12176.00.36‡ (0.27–0.44)

  • ↵N = number of lesions (*) or subjects in analysis; n = number of lesions (*) or subjects in region meeting criterion.

  • ↵† P < 0.05.

  • ↵‡ Fleiss’ κ.

  • Agreement is number of lesions, regions, or subjects that are concordant, as a percentage of lesion, regions, or subjects assessed. Cohen’s κ-coefficient reported for between-reader agreement. Fleiss κ-coefficient reported for multiple-reader agreement.

  • Data in parentheses are 95% confidence intervals.