TABLE 1

Selection of Peptide Receptors Coexpressed in Specific Cancer Types

Cancer typePeptide receptorIncidence in cancerReferences
NETs
 IlealSomatostatin (sst2 > sst3 > sst5 or sst1)sst2 > 90%4,7
CCK260%7,12
GIP86%10,14
GLP-130%7,8,14
Glucagon35%
 InsulinomasGLP-1>90%7,8,14
GIP100%10,14
Glucagon>90%
Somatostatin (sst1, sst5, sst2)70%4,7
 MTCCCK2>90%12
GIP89%15
Somatostatin (sst2)100% (antagonist)25
Non-NETs
 Prostate cancerGRP>90%16,17
PSMA*>90%18
 Breast cancerGRP65%–75%20,23
NPY (Y1 subtype)66%–85%22
Somatostatin (sst2)>90% (antagonist)2325
 GISTGRP84%26
CCK263%26
VPAC284%26
 Ewing sarcomaNeurotensin (NT1 subtype)64%27
NPY (Y1 subtype)84%28
 GlioblastomaSubstance P (NK1)100%29
NPY (Y2 subtype)83%30
  • * Does not belong to peptide receptor family.

  • Tested with iodinated somatostatin receptor antagonist JR11.

  • VPAC2 = subtype 2 of vasoactive intestinal polypeptide receptor; NK1 = neurokinin 1 subtype of tachykinin receptors.