Performance of 4 Radiologic Evaluation Criteria Applied to Early (3–4 Week) PET/CT Scans in Predicting Best Overall Response (RECIST 1.1) to ICI Therapy at ≥ 4 Months
| Response evaluation criteria | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) |
| RECIST1.1 | 100.0 (48.0–100.0) | 66.7 (38.4–88.1) | 50.0 (18.9–81.1) | 100.0 (69.0–100.0) | 75.0 |
| irRC | 80.0 (28.8–96.7) | 66.7 (38.4–88.1) | 44.4 (14.0–78.6) | 90.9 (58.7–98.5) | 70.0 |
| PERCIST | 60.0 (15.4–93.5) | 73.3 (44.9–92.0) | 42.9 (10.4–81.2) | 84.6 (54.5–97.6) | 70.0 |
| EORTC | 40.0 (6.5–84.6) | 73.3 (44.9–92.0) | 33.3 (5.3–77.3) | 78.6 (49.2–95.1) | 65.0 |
PPV = positive predictive value; NPV = negative predictive value.
Data in parentheses are 95% confidence intervals.