Distribution of Low and High GRPR Expression Within Different Categories of ER-Positive Tumors
| GRPR expression | |||||
| Characteristic | Category | No. of patients | Low % | High % | P |
| Age (y) | ≤40 | 65 | 29.2 | 70.8 | 0.006 |
| >40 | 1,217 | 16.1 | 83.9 | ||
| Histology* | IDC | 1,080 | 17.1 | 82.9 | 0.70 |
| ILC | 158 | 18.4 | 81.6 | ||
| Pathologic size (mm) | <20 | 883 | 14.9 | 85.1 | 0.009 |
| ≥20 | 399 | 20.8 | 79.2 | ||
| SBR grade* | I | 356 | 10.1 | 89.9 | <0.00001† |
| II | 643 | 14.9 | 85.1 | ||
| III | 267 | 29.6 | 70.4 | ||
| Ki-67 | <20% | 1,072 | 13.3 | 86.7 | <0.00001 |
| ≥20% | 210 | 30.0 | 70.0 | ||
| Lymph node status* | N0 | 762 | 16.0 | 84.0 | 0.052 |
| N+ | 414 | 20.5 | 79.5 | ||
| Estrogen receptor | 1%–9% | 18 | 44.4 | 55.6 | 0.005‡ |
| ≥10% | 1,264 | 16.4 | 83.6 | ||
| PR | 0% | 116 | 25.9 | 74.1 | 0.006 |
| ≥1% | 1,166 | 15.9 | 84.1 | ||
| AR | <10% | 91 | 33.0 | 67.0 | 0.00002 |
| ≥10% | 1,191 | 15.5 | 84.5 | ||
| HER2 overexpression | No | 1,183 | 16.7 | 83.3 | 0.91 |
| Yes | 99 | 17.2 | 82.8 | ||
↵* Patients with other histologic subtypes (n = 44) are excluded from statistical analysis. Number of patients with missing information regarding items: SBR grade, n = 16; lymph node status (Nx), n = 106.
↵† P value was calculated for SBR grade I + II vs. III.
↵‡ Statistical analysis based on χ2 or Fischer test.
IDC = invasive ductal carcinoma; ILC = invasive lobular carcinoma.