Radiation Dose Estimation, Extrapolated from Mice to Humans and Expressed as Mean Absorbed Dose (mGy/MBq), for 177Lu-OPS201, 90Y-OPS201, and 177Lu-DOTATATE
| Organ/tissue | 177Lu-OPS201 (10 pmol) | 90Y-OPS201 (10 pmol) | 177Lu-DOTATATE (10 pmol) | 177Lu-OPS201 (200 pmol) |
| Adrenals | 2.03E–01 | 9.71E–01 | 2.37E–01 | 3.79E–02 |
| Intestine | 3.79E–01 | 2.44E+00 | 3.38E–01 | 1.06E–01 |
| Stomach | 3.97E–01 | 1.64E+00 | 1.27E–01 | 6.19E–02 |
| Heart | 8.73E–03 | 2.83E–02 | 6.44E–03 | 2.48E–03 |
| Kidneys | 4.14E–01 | 1.72E+00 | 2.13E–01 | 4.06E–01 |
| Liver | 4.09E–02 | 1.78E–01 | 1.16E–02 | 1.67E–02 |
| Lungs | 2.45E–02 | 1.24E–01 | 4.07E–02 | 6.11E–03 |
| Muscle | 1.19E–03 | 0.00E+00 | 6.94E–04 | 4.05E–04 |
| Pancreas | 1.36E+00 | 7.88E+00 | 3.10E–01 | 3.00E–01 |
| Red marrow | 1.87E–03 | 1.29E–03 | 1.25E–03 | 6.63E–04 |
| Spleen | 4.71E–02 | 1.48E–01 | 3.13E–02 | 1.53E–02 |
| Salivary grands | 4.01E–01 | 1.78E+00 | 9.13E–02 | 6.58E–02 |
| Total body | 1.16E–02 | 5.81E–02 | 7.04E–03 | 4.60E–03 |
| Tumor (diameter, 4 cm) | 8.54E–01 | 2.85E+00 | 3.33E–01 | 7.50E–01 |
| Effective dose (mSv/MBq) | 9.08E–02 | 4.31E–01 | 3.17E–02 | 1.84E–02 |
| Tumor-to-organ ratio | ||||
| Tumor to kidney | 2.06 | 1.66 | 1.56 | 1.85 |
| Tumor to bone marrow | 457 | 2,209 | 266 | 1,131 |
| Tumor to spleen | 18.1 | 19.3 | 10.6 | 49.0 |
| Tumor to liver | 20.9 | 16.0 | 28.7 | 44.9 |