Distribution of Low and High GRPR Expression Within Different Categories of Breast Cancers
| GRPR expression | |||||
| Characteristic | Category | No. of patients | Low % | High % | P |
| Age (y) | ≤40 y | 85 | 45.9 | 54.1 | <0.00001 |
| >40 y | 1,347 | 22.9 | 77.1 | ||
| Histology* | IDC | 1,221 | 25.4 | 74.6 | 0.09 |
| ILC | 161 | 19.3 | 80.7 | ||
| Pathologic size (mm) | <20 | 961 | 20.9 | 79.1 | 0.00003 |
| ≥20 | 471 | 31.0 | 69.0 | ||
| SBR grade* | I | 358 | 10.6 | 89.4 | <0.00001† |
| II | 661 | 16.9 | 83.1 | ||
| III | 397 | 48.6 | 51.4 | ||
| Ki-67 | <20% | 1,115 | 17.0 | 83.0 | <0.00001 |
| ≥20% | 317 | 49.8 | 50.2 | ||
| Lymph node status* | N0 | 848 | 23.3 | 76.7 | 0.03 |
| N+ | 472 | 28.8 | 71.2 | ||
| ER | 0% | 150 | 88.0 | 12.0 | <0.00001 |
| ≥1% | 1,282 | 16.8 | 83.2 | ||
| PR | 0% | 266 | 60.9 | 39.1 | <0.00001 |
| ≥1% | 1,166 | 15.9 | 84.1 | ||
| AR | <10% | 184 | 63.0 | 37.0 | <0.00001 |
| ≥10% | 1,248 | 18.5 | 81.5 | ||
| HER2 overexpression | No | 1,286 | 22.8 | 77.2 | 0.0001 |
| Yes | 146 | 37.0 | 63.0 | ||
↵* Patients with other histologic subtypes (n = 50) are excluded from statistical analysis. Number of patients with missing information regarding items: SBR grade, n = 16; lymph node status (Nx), n = 112. Statistical analysis based on χ2 test.
↵† P value was calculated for SBR grade I + II vs. III.
IDC = invasive ductal carcinoma; ILC = invasive lobular carcinoma.