TABLE 2

Univariate and Multivariate Analysis of Predictors of High GRPR Expression

			Univariate analysis		Multivariate analysis
Characteristic	Category	No. of patients	P	Odds ratio	P	Odds ratio
Age (y)	<40	85	<0.0001	1	Nonsignificant (not retained)
	41–50	287	<0.0001	2.897 (1.742–4.816)
	>50	1,060	<0.0001	2.851 (1.818–4.472)
Histology	IDC	1,221	0.0389	1	Not retained
	ILC	161	0.0910	1.427 (0.945–2.155)
	Other	43	0.0479	2.586 (1.009–6.628)
Pathologic size (mm)	≥20	471	<0.0001	1	Not retained
	<20	961		1.699 [1.324 ; 2.180]
SBR grade	Grade III	397	<0.0001	1	0.0005	1
	Grade II	661	<0.0001	4.637 (3.495–6.154)	0.0023	1.831 (1.242–2.699)
	Grade I	358	<0.0001	7.965 (5.395–11.761)	0.0002	2.617 (1.591–4.303)
Ki-67	≥20%	317	<0.0001	1	0.0196	1
	<20%	1,115		4.869 (3.716–6.378)		1.584 (1.076–2.330)
Lymph node status	N⁺	472	0.0006	1	0.0350	1
	N₀	848	0.0289	1.329 (1.030–1.715)	0.3117	1.173 (0.861–1.597)
	Missing	112	0.0003	3.082 (1.672–5.681)	0.0103	2.636 (1.257–5.526)
ER	0%	150	<0.0001	1	<0.0001	1
	≥1%	1,282		36.394 (21.772–60.837)		11.998 (5.980–24.075)
PR	0%	266	<0.0001	1	0.0429	1
	≥1%	1,166		8.259 (6.167–11.061)		1.652 (1.016–2.686)
AR	<10%	184	<0.0001	1	0.0027	1
	≥10%	1,248		7.509 (5.389–10.462)		2.011 (1.275–3.173)
HER2 overexpression	Yes	146	0.0002	1	0.0038	1
	No	1,286		1.989 (1.387–2.852)		0.461 (0.273–0.779)

IDC = invasive ductal carcinoma; ILC = invasive lobular carcinoma.
Statistical analysis based on Cox model; P < 0.05 was considered significant. Data in parentheses are 95% CIs.