Estimated Kinetic Parameters and VT (±SD) as Obtained by 2TCM-4k_Vb
| Brain region | Vb | K1 | k2 | k3 | k4 | VT |
| Precuneus | ||||||
| HC | 0.05 ± 0.01 | 0.77 ± 0.12 | 0.17 ± 0.02 | 0.02 ± 0.01 | 0.02 ± 0.01 | 8.5 ± 2.9 |
| aMCI | 0.05 ± 0.01 | 0.69 ± 0.15 | 0.14 ± 0.04 | 0.03 ± 0.01 | 0.02 ± 0.005 | 12.1* ± 3.0 |
| AD | 0.05 ± 0.01 | 0.63* ± 0.10 | 0.13* ± 0.03 | 0.03 ± 0.01 | 0.02 ± 0.007 | 12.6* ± 1.6 |
| CB | ||||||
| HC | 0.05 ± 0.01 | 0.66 ± 0.12 | 0.17 ± 0.03 | 0.01 ± 0.01 | 0.02 ± 0.01 | 7.5 ± 2.3 |
| aMCI | 0.06 ± 0.01 | 0.65 ± 0.11 | 0.17 ± 0.03 | 0.01 ± 0.01 | 0.01 ± 0.01 | 8.3 ± 2.3 |
| AD | 0.05 ± 0.01 | 0.59 ± 0.09 | 0.16 ± 0.03 | 0.01 ± 0.003 | 0.01 ± 0.01 | 8.3 ± 2.0 |
| WM | ||||||
| HC | 0.02 ± 0.01 | 0.28 ± 0.06 | 0.14 ± 0.04 | 0.19 ± 0.10 | 0.04 ± 0.01 | 10.9 ± 3.0 |
| aMCI | 0.02 ± 0.01 | 0.26 ± 0.05 | 0.13 ± 0.04 | 0.16 ± 0.11 | 0.03 ± 0.02 | 11.5 ± 2.3 |
| AD | 0.02 ± 0.01 | 0.25 ± 0.04 | 0.11 ± 0.04 | 0.12* ± 0.04 | 0.03 ± 0.01 | 10.9 ± 1.7 |
↵* Significantly different from controls (1-way ANOVA, corrected for multiple comparisons via Dunnett, P < 0.05).