TABLE 3

Biodistribution of ¹⁷⁷Lu-OPS201 and ¹⁷⁷Lu-DOTATATE 4 Hours After Injection in Nude Mice Bearing HEK-hsst2 Tumor Xenografts: A Mass-Escalation Study

Organ	10 pmol	200 pmol	2,000 pmol
¹⁷⁷Lu-OPS201
Blood	0.10 ± 0.02	0.03 ± 0.01	0.02 ± 0.01
Heart	0.61 ± 0.09	0.11 ± 0.03	0.04 ± 0.01
Lung	6.59 ± 3.41	1.34 ± 0.95	0.26 ± 0.04
Liver	1.45 ± 0.33	0.47 ± 0.15	0.24 ± 0.07
Pancreas	47.0 ± 4.20	10.7 ± 2.80	0.96 ± 0.45
Spleen	1.39 ± 0.69	0.25 ± 0.05	0.12 ± 0.03
Stomach	49.8 ± 8.19	7.55 ± 1.45	1.02 ± 0.14
Intestine	9.46 ± 2.24	1.96 ± 0.38	0.36 ± 0.10
Adrenal	8.16 ± 1.72	1.63 ± 0.64	0.38 ± 0.10
Kidney	5.88 ± 0.85	6.43 ± 1.60	6.23 ± 1.91
Muscle	0.10 ± 0.03	0.03 ± 0.01	0.03 ± 0.01
Femur	1.24 ± 0.92	0.31 ± 0.15	0.14 ± 0.03
Salivary gland	2.32 ± 0.47	0.36 ± 0.21	0.11 ± 0.02
Tumor	23.9 ± 4.76	24.9 ± 6.24^*	18.8 ± 2.13^†
¹⁷⁷Lu-DOTATATE
Blood	0.07 ± 0.01	0.03 ± 0.02	0.02 ± 0.00
Heart	0.29 ± 0.06	0.06 ± 0.02	0.02 ± 0.00
Lung	6.54 ± 3.49	1.58 ± 0.90	0.19 ± 0.08
Liver	0.26 ± 0.04	0.13 ± 0.03	0.06 ± 0.01
Pancreas	10.3 ± 1.66	3.48 ± 1.77	0.40 ± 0.13
Spleen	0.76 ± 0.18	0.14 ± 0.03	0.05 ± 0.01
Stomach	12.2 ± 2.23	4.07 ± 1.05	0.53 ± 0.10
Intestine	5.80 ± 1.20	1.59 ± 0.30	0.24 ± 0.07
Adrenal	9.27 ± 2.49	2.32 ± 1.31	0.49 ± 0.05
Kidney	5.10 ± 0.94	4.02 ± 1.18	3.41 ± 0.17
Muscle	0.03 ± 0.01	0.02 ± 0.01	0.01 ± 0.00
Femur	1.55 ± 0.36	0.23 ± 0.18	0.06 ± 0.03
Salivary gland	0.68 ± 0.40	0.19 ± 0.16	0.04 ± 0.02
Tumor	17.8 ± 4.35	12.0 ± 2.16^‡	9.94 ± 2.52^¶

↵* P = 0.7948, compared with 10 pmol ¹⁷⁷Lu-OPS201.
↵† P = 0.0813, compared with 10 pmol ¹⁷⁷Lu-OPS201.
↵‡ P = 0.0450, compared with 10 pmol ¹⁷⁷Lu-DOTATATE.
↵¶ P = 0.0249, compared with 10 pmol ¹⁷⁷Lu-DOTATATE.
Data are %IA/g ± SD, n = 3–6.