TABLE 1

Binding Properties of 10 Amyloid PET Radioligands

	K_D (nM)			Clinical SUVR (−)
Radioligand	Aβ_1–40	Aβ_1–42	Ref.	Interval (min)	Region	Healthy	AD	Ref.
¹¹C-PIB	1.02, 0.90, 3.30, 4.70, (2.48)^*	0.91, 0.95, (0.93)^*	1,37–39	40–60	Posterior cingulate	1.32	2.79	2
¹¹C-BF-227	1.8	4.3	5	40–60	Temporal occipital	1.32	1.65	4
¹¹C-AZD2184	8.40	—	38	40–60	Posterior cingulate	1.24	2.54	7
¹¹C-SB-13	2.43^†		8	40–120	Left frontal	—	1.34	8
¹⁸F-FACT	9.40	—	30	40–60	Temporal occipital	1.25	1.33	4
¹⁸F-florbetapir	3.72^†		40	50–60	Precuneus	1.30	1.85	9
¹⁸F-florbetaben	2.22^‡		41	90–120	Gyrus rectus	1.37	2.15	11
¹⁸F-flutemetamol	1.60	—	42	85–115	Precuneus	1.36	2.16	13
¹⁸F-FDDNP	0.12	5.52	32,43	45–55	Anterior cingulate	1.24	1.37	14
¹⁸F-AZD4694	2.30	—	42	51–63	Prefrontal	1.15	2.88	36

↵* Averaged K_D.
↵† Binding affinity to brain homogenate in AD subject.
↵‡ K_D with florbetapir to brain homogenate in AD subject.
Ref. = reference.