Predicted and Clinical BPND (−) for 9 Amyloid PET Radioligands
| Clinical BPND | ||||
| Radioligand | Predicted BPND (Bavail = 50 nM) | AD | ROI | Ref. |
| 11C-PIB | 5.44 | 1.51 | Posterior cingulate* | 2 |
| 11C-BF-227 | 2.16 | 0.50 | Temporal occipital* | 4 |
| 11C-AZD2184 | 2.63 | 1.39 | Posterior cingulate* | 7 |
| 11C-SB-13 | 0.81 | — | — | — |
| 18F-FACT | 1.94 | 0.28 | Temporal occipital* | 4 |
| 18F-florbetapir | 1.70 | 0.60 | Putamen† | 9 |
| 18F-florbetaben | 1.09 | 0.75 | Global cortex*‡ | 45 |
| 18F-flutemetamol | 2.49 | 0.93 | Posterior cingulate* | 46 |
| 18F-FDDNP | 0.88 | 0.07 | Global cortex§∥ | 33 |
| 18F-AZD4694 | 3.26 | 1.26 | Posterior cingulate* | 36 |
↵* Estimated BPND (DVR-1) from target VT and cerebellar VT in 2-tissue-compartment model.
↵† Estimated BPND (DVR-1) from graphical plot (Zhou’s method).
↵‡ Frontal, lateral temporal, parietal, and posterior cingulate cortices.
↵§ Estimated BPND (simplified reference tissue model).
↵∥ Orbital frontal, medial inferior frontal, anterior cingulate, superior temporal, parietal, medial inferior temporal, superior frontal, and entorhinal cortices and hippocampus.
Ref. = reference.