Independent Components Identified as Pathophysiologically Significant in Each Group
| NA | NC MCI | MCI > 2 y | MCI ≤ 2 y | AD | ||||||||||
| IC | Size | Regions | IC | Size | Regions | IC | Size | Regions | IC | Size | Regions | IC | Size | Regions |
| 3 | 2,309 | DLFC+MFG | ||||||||||||
| 6 | 907 | SMA, premotor, and BA9 | ||||||||||||
| 4 | 2,408 | PCC+iPL (postDMN) | 6 | 3,210 | PCC+iPL (postDMN) | |||||||||
| 14 | 813 | Basal ganglia | 7 | 1,277 | Basal ganglia | 19 | 2,960 | Basal ganglia+thalamic | ||||||
| 15 | 5,083 | Primary visual | 16 | 3,117 | Primary visual | 7 | 5,346 | Primary visual | 10 | 5,721 | Primary visual | 1&9 | 8,783 | Primary visual |
| 1 | 5,971 | Cerebellum | 14 | 2,679 | Cerebellum | 4 | 5,358 | Cerebellum | 4 | 5,183 | Cerebellum | 3 | 5,178 | Cerebellum |
| 7 | 1,470 | L sPL | 1 | 1,756 | L sPL+L DLFC+L T | |||||||||
| 8 | 891 | R sensorimotor | 16 | 1,493 | R sensorimotor | 19 | 2,370 | Sensorimotor | 10 | 3,588 | Sensorimotor | |||
| 15 | 1,702 | Sylvian temporal | 3 | 4,161 | Sylvian temporal | 3 | 4,464 | Sylvian temporal | 8 | 3,121 | Sylvian temporal | |||
| 1 | 1,038 | L DLFC | ||||||||||||
| 2 | 1,700 | iPL+O | ||||||||||||
| 12 | 787 | VLFC | ||||||||||||
| 9 | 4,691 | R iPL+R T | 5 | 5,190 | R iPL+R T | 5 | 4,466 | iPL+R T | ||||||
| 17 | 2,922 | R iPL+R O+R T | 15 | 4,000 | R iPL+R O | |||||||||
| 12 | 1,748 | Thalami | ||||||||||||
| 13 | 2,231 | L O | ||||||||||||
| 1 | 1,129 | R MTL | 6 | 1,357 | MTL | |||||||||
| 2 | 2,565 | VLFC | 18 | 3,888 | VLFC | |||||||||
| 6 | 4,427 | sPL | 13 | 5,119 | sPL | |||||||||
| 12 | 3,700 | PCC | 7 | 3,343 | PCC+PC | |||||||||
| 8 | 1,894 | O | ||||||||||||
| 9 | 4,281 | L sPL+PC+L T | ||||||||||||
| 13 | 1,526 | DLFC | ||||||||||||
| 14 | 2,978 | L T | ||||||||||||
| 16 | 2,959 | L T | ||||||||||||
| Voxel extent | 17,491 | 16,594 | 29,706 | 43,727 | 51,740 | |||||||||
| Number | 9 | 9 | 9 | 13 | 14 | |||||||||
NA = normal aging; NC = nonconverting; MCI > 2 y = MCI converting after more than 2 y; MCI ≤ 2 y = MCI converting within 2 y; IC = independent component; DLFC = dorsolateral frontal cortex; MFG = medial frontal gyrus; SMA = supplementary motor area; BA = Brodmann area; PCC = posterior cingulate cortex; iPL = inferior parietal lobule; postDNM = posterior default-mode network; L = left; sPL superior parietal lobule; T = temporal; R = right; O = occipital; VLFC = ventrolateral frontal cortex; MTL = mesial temporal lobe; PC = precuneus.