TABLE 3

Predicted and Clinically Estimated K₁ and k₂ of 8 Amyloid PET Radioligands in Cortical Region

	K₁ (mL/100 g/min)			k₂ (min⁻¹)
		Clinical K₁			Clinical k₂
Radioligand	Predicted K₁	Healthy	AD	Predicted k₂	Healthy	AD	Regions of interest for clinical study	Ref.
¹¹C-PIB	0.73	0.29	0.26	0.40	0.17	0.12	Middle precuneus	44
¹¹C-BF-227	0.63	0.27	0.23	0.34	0.13	0.12	Temporal occipital	4
¹¹C-AZD2184	0.69	0.32	0.26	0.58	0.52	0.30	Posterior cingulate	7
¹¹C-SB-13	0.60	—	—	0.19	—	—	—	—
¹⁸F-FACT	0.57	0.22	0.20	0.44	0.23	0.16	Temporal occipital	4
¹⁸F-florbetapir	0.54	—	—	0.28	—	—	—	—
¹⁸F-florbetaben	0.47	0.22	0.19	0.16	0.085	0.076	Frontal cortex	45
¹⁸F-flutemetamol	0.69	0.25	0.23	0.29	0.080	0.080	Global cortex^*	34
¹⁸F-FDDNP	0.58	0.25	0.36	0.23	0.060	0.060	Global cortex^†	33
¹⁸F-AZD4694	0.75	0.34	0.23	0.41	0.30	0.14	Posterior cingulate	36

↵* Frontal, parietal, anterior cingulate, posterior cingulate, and temporal cortices.
↵† Orbital frontal, medial inferior frontal, anterior cingulate, superior temporal, parietal, medial inferior temporal, superior frontal, and entorhinal cortices and hippocampus.
Ref. = reference.
Clinical K₁ and k₂ for healthy and AD groups were estimated using 2-tissue-compartment model with measured arterial input function.