Reproducibility of Kinetic Rate Constants Using 20-Minute TD*
| Tumor level (n = 248) | Voxel level | ||||||||
| Kinetic rate constant | r | Slope (95% CI) | Intercept (95% CI) | RMSD | Mean difference (95% LoA) | r | Slope | Intercept | Mean difference (95% LoA) |
| K3 (min−1) | 0.98 | 1.000 (0.977 to 1.003) | 3E−5 (−6E−5 to 1E−4) | 0.0005 ± 0.0004 | 3.5E−5 (−0.0008 to 0.0009) | 0.98 | 1.034 | −9E−6 | 1.1E−4 (−0.0015 to 0.0017) |
| K1 (min−1) | 1.00 | 0.966 (0.955 to 0.977) | 0.016 (0.012 to 0.020) | 0.017 ± 0.010 | 0.004 (−0.024 to 0.033) | 0.99 | 0.971 | 0.017 | 0.007 (−0.042 to 0.057) |
| K1/k2 | 0.98 | 1.073 (1.045 to 1.100) | −0.08 (−0.11 to −0.06 | 0.06 ± 0.03 | −0.02 (−0.09 to 0.06) | 0.96 | 1.064 | −0.08 | −0.02 (−0.16 to 0.12) |
| vB | 0.99 | 0.992 (0.977 to 1.007) | −3E−3 (−6E−3 to 2E−8) | 0.01 ± 0.01 | −0.004 (−0.026 to 0.017) | 0.98 | 0.977 | −4E−4 | −0.005 (−0.045 to 0.036) |
| DV | 0.98 | 1.088 (1.060 to 1.115) | −0.10 (-0.12 to −0.07) | 0.04 ± 0.02 | −0.01 (−0.08 to 0.05) | 0.96 | 1.073 | −0.09 | −0.02 (−0.13 to 0.09) |
↵* 0- to 10-min dynamic + 10-min static acquisition starting at 160 min after injection (20-min total acquisition time).
CI = confidence interval; RMSD = root-mean-square deviation; LoA = limits of agreement.