Reproducibility of Kinetic Rate Constants Using 15-Minute TD*
| Tumor level (n = 248) | Voxel level | ||||||||
| Kinetic rate constant | r | Slope (95% CI) | Intercept (95% CI) | RMSD | Mean difference (95% LoA) | r | Slope | Intercept | Mean difference (95% LoA) |
| k3 (min−1) | 0.95 | 1.057 (1.010 to 1.103) | 7E−5 (−9E−5 to 2E−4) | 0.0011 ± 0.0009 | 0.0002 (−0.0014 to 0.0015) | 0.91 | 1.070 | 5E−5 | 0.0003 (−0.0032 to 0.0037) |
| K1 (min−1) | 0.99 | 0.948 (0.931 to 0.965) | 0.033 (0.026 to 0.040) | 0.035 ± 0.018 | 0.015 (−0.029 to 0.058) | 0.98 | 0.962 | 0.031 | 0.019 (−0.065 to 0.102) |
| K1/k2 | 0.92 | 1.089 (1.025 to 1.154) | −0.11 (−0.18 to −0.05 | 0.14 ± 0.06 | −0.03 (−0.18 to 0.12) | 0.81 | 1.072 | −0.11 | −0.04 (−0.37 to 0.29) |
| vB | 0.99 | 0.981 (0.958 to 1.004) | −5E−3 (−9E−3 to 3E−3) | 0.02 ± 0.01 | −0.008 (−0.039 to 0.022) | 0.97 | 0.970 | −3E−3 | −0.009 (−0.061 to 0.043) |
| DV | 0.93 | 1.124 (1.059 to 1.188) | −0.15 (−0.21 to −0.08) | 0.12 ± 0.05 | −0.03 (−0.16 to 0.10) | 0.82 | 1.095 | −0.13 | −0.04 (−0.30 to 0.22) |
↵* 0- to 5-min dynamic + 10-min static acquisition starting at 160 min after injection (15-min total acquisition time).
CI = confidence interval; RMSD = root-mean-square deviation; LoA = limits of agreement.