Striatal occupancy and functional response from 5-HT4 drugs
DrugDose (mg/kg)pretreatment% Occupancy (PET)% change in CBV (fMRI)
RS673330.01N.A.24N.D.
RS673330.05N.A.48N.D.
RS673330.20N.A.90N.D.
SB2071450.25N.A.90+N.D.
SB2071450.25fenfluramine (5 mg/kg)N.A.N.D.
N.A.: Not applicable; N.D.: Not detectible