Table 1. Effects of PD-L1 mAb dose escalation on Zr-89 PD-L1 mAb Tissue:Muscle ratios
| Tissue: Muscle Ratios 3 d post injection [mean (SD); n=5,6] | |||||
| PD-L1 mAb dose (ug) [coinjected with Zr-89 PD-L1 mAb (2 ug) ] | 0 | 10 | 20 | 40 | 400 |
| Spleen | 42.6 (8.4) | 39.5 (10.8) | 23.6 (3.5) | 9.2 (1.8) | 4.4 (0.4) |
| Lymph nodes | 9.4 (1.6) | 11.3 (3.9) | 43.3 (9.7) | 19.4 (4.4) | 11.5 (2.2) |
| MDA-MB231 tumor | 3.1 (0.6) | 2.2 (0.4) | 10.6 (2.1) | 10.0 (1.7) | 8.9 (2.3) |