TABLE 1

Characteristics of Included Trials

StudyTimelineRadioligandNo. of patientsChange in managementChange in management (any or surgical only)Change in intended or implemented managementResponse ratesData acquisition (review or questionnaire)Responding entityState of disease (primary or any)Prior conventional imaging*
Frilling et al. (27)Retrospective68Ga-DOTATOC5231 (60%)AnyImplemented100%ReviewIndependent expert commissionAnyYes
Ambrosini et al. (28)Retrospective68Ga-DOTANOC9032 (36%)AnyImplementedN/AQuestionnaireReferring physicianAnyYes
Ruf et al. (29)Retrospective68Ga-DOTATOC6424 (38%)AnyImplemented97%ReviewIndependent expert commissionAnyYes
Srirajaskanthan et al. (21)Retrospective68Ga-DOTATATE5136 (71%)AnyImplemented16%ReviewIndependent expert commissionAnyYes
Naswa et al. (23)Prospective68Ga-DOTANOC10921 (19%)AnyImplemented100%ReviewReferring physicianAnyYes
Krausz et al. (12)Prospective68Ga-DOTANOC193 (16%)AnyIntended100%ReviewReferring physicianAnyYes
Froeling et al. (31)Retrospective68Ga-DOTATOC2110 (48%)AnyImplementedN/AReviewReferring physicianAnyNo
Hofman et al. (32)Retrospective68Ga-DOTATATE5934 (58%)AnyImplementedN/AReviewIndependent expert commissionAnyYes
Has Simsek et al. (33)Prospective68Ga-DOTATATE2716 (59%)AnyIntended100%ReviewIndependent expert commissionAnyYes
Herrmann et al. (30)Prospective68Ga-DOTATATE8853 (60%)AnyIntended88%QuestionnaireReferring physicianAnyYes
Ilhan et al. (34)Retrospective68Ga-DOTATATE449 (20%)Surgical OnlyImplementedN/AReviewIndependent expert commissionPrimaryNo
Sadowski et al. (20)Prospective68Ga-DOTATATE13043 (33%)AnyIntended100%ReviewReferring physicianAnyYes
Skoura et al. (19)†Retrospective68Ga-DOTATATE1,258†515† (41%)AnyImplementedN/AReviewIndependent expert commissionAnyUnknown
Deppen et al. (22)Retrospective68Ga-DOTATATE7828 (36%)AnyIntended80%ReviewIndependent expert commissionAnyYes

  • ↵* Conventional imaging includes bone scanning, ultrasound, MRI, CT, Octreoscan, and 18F-FDG PET/CT.

  • ↵† This study recorded total number of scans and was analyzed on a per-scan basis; number of patients in their study was 728.