TABLE 3

Univariate and Multivariate Analysis of Prognostic Factors for OS in Extrahepatic BCLC Stage C HCC Patients (n = 138)

		Univariate		Multivariate
Variable	n	HR	P	HR	P
Age (y)		0.75 (0.52–1.08)	0.12
<57	77
≥57	61
Sex		1.02 (0.62–1.69)	0.94
Male	117
Female	21
Etiology		0.90 (0.74–1.09)	0.27
HBV	108
HCV	10
Alcohol	7
Unknown	13
Child–Pugh classification		1.97 (1.26–3.08)	0.003	1.48 (0.93–2.36)	0.1
A	111
B	27
AFP (ng/mL)		1.35 (0.95–1.93)	0.1
<1,466	66
≥1,466	72
PIVKA-II (mAU/mL)		1.30 (0.89–1.89)	0.18
<1,200	57
≥1,200	74
Tumor size		1.71 (1.19–2.45)	0.005	1.46 (0.99–2.14)	0.06
<10.3	67
≥10.3	71
Tumor number		1.54 (1.04–2.27)	0.03	1.42 (0.94–2.13)	0.09
<4	46
≥4	92
Portal vein invasion		1.59 (1.09–2.31)	0.02	1.18 (0.79–1.77)	0.41
Absence	55
Presence	83
TLR		1.78 (1.21–2.61)	0.003	1.69 (1.13–2.51)	0.01
<3.2	49
≥3.2	89

HR = hazard ratio; HBV = hepatitis B virus; HCV = hepatitis C virus.
Data in parentheses are 95% confidence intervals.