TABLE 1

Summary of Kinetic Parameters and Corresponding Truncation Limits Used for the Simulation of Preclinical and Clinical Tumor Tissue Classes

	Class 1		Class 2		Class 3
Kinetic parameter	Preclinical	Clinical	Preclinical	Clinical	Preclinical	Clinical	Truncation limits
K₁	0.138 ± 0.043	0.110 ± 0.034	0.123 ± 0.033	0.114 ± 0.026	0.045 ± 0.006	0.036 ± 0.005	0.01–1.0
k₂	0.116 ± 0.136	0.195 ± 0.228	0.180 ± 0.069	0.301 ± 0.116	0.105 ± 0.025	0.176 ± 0.042	0.01–1.0
k₃	0.085 ± 0.056	0.073 ± 0.048	0.014 ± 0.008	0.012 ± 0.007	0.005 ± 0.002	0.004 ± 0.001	0.001–1.0

Data are mean ± SD.