Octanol–Phosphate-Buffered Saline Distribution Coefficients and αvβ6 Integrin Affinities for 68Ga-Labeled αvβ6 Integrin Ligands
| Compound | log D | IC50 (pm) |
| 68Ga-NODAGA-AvB6 | −2.41 ± 0.05 | 267 ± 31 |
| 68Ga-Avebehexin | −3.71 ± 0.03 | 260 ± 17 |
| 68Ga-TRAP(AvB6)2 | −2.14 ± 0.11 | 120 ± 23 |
| 68Ga-TRAP(AvB6)3 | −1.72 ± 0.04 | 23 ± 4 |
| 68Ga-TRAP(PEG10-AvB6)3 | −1.94 ± 0.13 | 87 ± 12 |
Affinities were determined using nonradioactive 69/71GaIII complexes.
IC50 = 50% inhibition concentration.