Evaluated Models and Corresponding Primary Outcome Parameter
| Type | Model | Outcome |
| Arterial-based | ||
| 1 | 1TCM | VT = K1/k2 |
| 2 | 2TCM ± K1/k2 coupled | VS = K1*k3/k2*k4 |
| 3 | 3TCM ± K1/k2 coupled | VS = K1*k3/k2*k4 |
| 4 | Logan plot | VT |
| Reference region | ||
| 5 | SRTM2 ± k2’ fixed | BPND = k3/k4 |
| 6 | Logan reference plot | DVR = BPND + 1 |
| Ratio method | ||
| 7 | Target/ref | SUVR = CT/Ccerebellum |
| 8 | SUV | SUV = CT/injected dose |
Reference models used cerebellar gray matter as reference region. Ratio methods were calculated as activity of target region divided by activity in reference region (SUVR = target/ref) or divided by injected dose per kg of body weight (SUV). Different time intervals are presented in Table 2.
CT = concentration in target region.