TABLE 1

Uptake of 99mTc-Duramycin in COLO205 and HT29 Xenografts 24 Hours After Treatment and Tumor-to-Background Ratios

COLO205HT29
ParameterIgG1ConatumumabIgG1Conatumumab
Blood uptake (%ID/g)0.39 ± 0.080.39 ± 0.080.34 ± 0.010.36 ± 0.01
Muscle uptake (%ID/g)0.15 ± 0.020.16 ± 0.020.15 ± 0.010.15 ± 0.01
Tumor-to-blood ratio1.83 ± 0.3214.93 ± 1.32*3.41 ± 0.843.96 ± 0.78
Tumor-to-muscle ratio4.45 ± 0.9230.80 ± 1.89†7.40 ± 1.669.53 ± 1.85

  • ↵* P = 0.003.

  • ↵† P < 0.001.

  • Data are mean ± SEM.