TABLE 2

Brain Areas with Significantly Decreased Uptake of ¹⁸F-FDG^*

				Peak value coordinates (mm)
Group and K value	Brain area	Side	Label	x	y	z	T value	P
Whole group (n = 100)
328	Cerebellum	L	CPL	−22	−72	−60	4.82	<0.001
284	Cerebellum	R	CPL	36	−66	−62	4.29	<0.001
3,901	Occipital lobe, limbic lobe, cerebellum, sublobar region	L, R	BA18-BA19-BA30-BA17-BA23-BA31-BA7-CAL-CPL	−12	−70	6	4.06	<0.001
455	Temporal lobe, parietal lobar	R	BA21-BA22-BA39-BA40	66	−46	4	3.56	<0.001
439	Temporal lobe, occipital lobe	L	BA37-BA39-BA21-BA22-BA19	−56	−54	0	3.55	<0.001
207	Frontal lobe	L, R	BA11-BA47	−8	22	−32	3.51	<0.001
236	Sublobar region, temporal lobe	L	BA13-BA38	−36	4	−8	3.47	0.001
271	Occipital lobe	L	BA19-BA18	−42	−86	0	3.33	0.001
233	Sublobar region, temporal lobe	R	BA13-BA21	40	−2	−8	3.11	0.001
FSC dysfunction (n = 29)
33,436	Occipital lobe, parietal lobe, frontal lobe, temporal lobe, limbic lobe, sublobar region, cerebellum	L, R	BA19-BA18-BA40-BA7-BA6-BA31-BA21-BA22-BA37-BA13-BA17-BA2-BA4-BA3-BA39-BA30-BA23-BA9-BA44-BA42-BA46-BA1-BA41-BA8-BA45-BA10-BA20-BA47-BA43-BA5-BA36-BA29-BA24-CAL-CPL	−14	−66	66	4.78	<0.001
251	Frontal lobe	R	BA11-BA47	10	40	−26	3.71	<0.001
681	Midbrain, sublobar region, limbic lobe, temporal lobe	L, R	BA27-BA30-BA35-BA28	4	−24	−6	3.39	0.001
256	Frontal lobe, limbic lobe	L, R	BA6-BA31	−2	−18	56	3.32	0.001
349	Frontal lobe	L	BA10-BA9-BA46	−34	40	34	3.25	0.001
250	Parietal lobe	L, R	BA7-BA5	−8	−46	78	3.20	0.001
Papez circuit dysfunction (n = 22)
766	Frontal lobe	R	BA6-BA8	28	−4	72	3.98	<0.001
1,084	Sublobar region, frontal lobe, temporal lobe, parietal lobe	L	BA13-BA44-BA41-BA47-BA22-BA45-BA6-BA43	−38	14	2	3.83	<0.001
6,494	Occipital lobe, parietal lobe, limbic lobe, cerebellum, frontal lobe, temporal lobe	L, R	BA19-BA18-BA40-BA7-BA31-BA30-BA17-BA23-BA2-BA3-BA37-BA1-BA4-BA29-BA22-BA36-CAL-CPL	−14	−64	68	3.80	<0.001
2,411	Temporal lobe, frontal lobe, sublobar region, parietal lobe	R	BA22-BA13-BA21-BA44-BA6-BA45-BA9-BA47-BA41-BA40-BA39	40	18	6	3.78	<0.001
399	Frontal lobe, limbic lobe	L, R	BA11-BA32-BA10-BA47	12	40	−26	3.64	<0.001
351	Frontal lobe	L	BA6	−24	−14	74	3.45	0.001
605	Midbrain, limbic lobe	L, R	BA27-BA30-BA35	0	−24	−4	3.38	0.001
516	Parietal lobe	R	BA7-BA40	44	−52	58	3.38	0.001
567	Parietal lobe, temporal lobe, frontal lobe	R	BA40-BA2-BA1-BA42-BA3-BA22-BA43-BA4	68	−34	22	3.18	0.001
256	Temporal lobe, occipital lobe	L	BA37-BA21-BA22-BA19	−58	−62	−8	3.14	0.001
231	Temporal lobe, parietal lobe	L	BA42-BA22-BA40-BA41-BA21	−66	−30	10	3.11	0.001
No significant cognitive impairment (n = 42)
4,325	Occipital lobe, temporal lobe, limbic lobe, parietal lobe, cerebellum	L, R	BA18-BA19-BA21-BA30-BA17-BA22-BA23-BA37-BA31-BA7-BA40-BA39-BA20-CAL	−12	−70	8	4.00	<0.001
583	Temporal lobe, occipital lobe	L	BA39-BA21-BA22-BA37-BA19	−58	−54	0	3.59	<0.001
333	Parietal lobe, frontal lobe	R	BA40-BA2-BA3-BA4-BA1-BA43	58	−32	40	3.55	<0.001
212	Occipital lobe	L	BA19-BA18	−42	−86	−4	3.34	0.001

↵* In comparison with control group. Results were collected at P value of <0.005 at voxel level for clusters k ≥ 200 contiguous voxels (corrected for cluster volume), with adjustment for age and sex. For patients with callosal disconnection (subgroup 4; n = 7), there were no significant voxels.
K value = number of significant voxels in particular cluster; L = left; CPL = cerebellum posterior lobe; R = right; BA = Brodmann area; CAL = cerebellum anterior lobe.