TABLE 1

Summary of Human Studies Evaluating Quantitative Parameters for ¹⁸F-FDG Uptake in Lungs

Cohort	Publication	No. of subjects	Parameters derived from PET imaging data	Correlative data
ARDS	Bellani et al., 2009 (19)	10	Patlak K_i	PFTs
ARDS	Bellani et al., 2011 (18)	13	Patlak K_i	PFTs
ARDS/HV	Grecchi et al., 2016 (20)	11/5	CM K_i, Patlak K_i, SUV	None
ARDS model in HV	Chen et al., 2006 (57)	18	Patlak K_i	BAL neutrophil ³H-deoxyglucose uptake
ARDS model in HV	Chen et al., 2009 (56)	18	Patlak K_i	BAL
Asthma–BC	Taylor et al., 1996 (24)	9	Patlak K_i	BAL
Asthma–BC	Harris et al., 2011 (8)	6	Patlak K_i	BAL
COPD/asthma/HV	Jones et al., 2003 (10)	6/6/5	Patlak K_iN	¹¹C-PBR28 uptake, PFT, sputum
COPD/HV/AATD COPD	Subramanian et al., 2012 (17)	10/10/10	Patlak K_iN	PFTs
COPD	Torigian et al., 2013 (39)	49	AFC SUV	None
Cystic fibrosis/control	Labiris et al., 2003 (16)	8/3	Patlak K_i	Sputum
Cystic fibrosis/HV	Chen et al., 2006 (7)	20/7	Patlak K_i, K_iN	BAL and PFTs
Cystic fibrosis	Klein et al., 2009 (25)	20	SUV	PFTs, WBC, CRP
Cystic fibrosis/control	Amin et al., 2012 (15)	20/10	SUV	PFTs, sputum, CT metrics
HV	Lambrou et al., 2011 (38)	12	AFC SUV	None
Interstitial lung diseases, including IPF	Groves et al., 2009 (11)	18 IPF/18 other interstitial lung diseases	SUV, TBR	PFTs
IPF	Umeda et al., 2015 (40)	50	Dual-time-point SUV	CT-derived fibrosis score, PFTs
IPF	Holman et al., 2015 (21)	6	ABC Patlak K_i, ABC CM K_i	None
IPF	Win et al., 2012 (22)	13	AFC SUV	None
IPF/control	Win et al., 2014 (23)	25/25	AFC SUV	None
Pneumonia/bronchiectasis	Jones et al., 1997 (9)	5/5	K_iN	None

AATD = α₁ antitrypsin deficiency; ABC = air- and blood-corrected; AFC = air fraction–corrected; BAL = bronchoalveolar lavage; BC = bronchoscopic challenge; CM = compartmental model; CRP = C-reactive protein; HV = healthy volunteer; K_iN = intercept-normalized K_i; PFT = pulmonary function test; TBR = target-to-background ratio.