Ligand | IC50 (nM) | Specific internalization (% of reference)* | Lipophilicity (log POW) | |
Ga-PSMA-I&T | 9.4 ± 2.9 | 68GaPSMA-I&T | 59 ± 2 | −4.3 |
Lu-PSMA-I&T | 7.9 ± 2.4 | 177LuPSMA-I&T | 76 ± 2 | −4.1 |
In-PSMA-I&T | 7.5 ± 1.5 | 111InPSMA-I&T | 104 ± 7 | −4.5 |
Mas3-y-nal-k(Sub-KuE) = PSMA-I&S (5) | 39.7 ± 1.2 | 99mTcPSMA-I&S | 93 ± 3 | −3.0 |
MAS3-y-naI-k(Sub-KuE) (6) | 47.6 ± 2.5 | 99mTc-6 | 78 ± 2 | −2.9 |
Re-PSMA-I&S (Re-5) | 15.5 ± 2.8 | |||
Re-MAS3-y-naI-k(Sub-KuE) (Re-6) | 12.4 ± 0.8 |
↵* Specific internalization of reference compound (125I-BA)KuE was determined in a parallel experiment and used for data normalization.
OW = octanol water.