TABLE 3

Thyroid-Associated Diseases and Functions in Liver

TissueTime pointDiseases and functionsAnnotationPMolecule
Liver1 hND
6 hND
24 hCancer, endocrine system disordersAsymptomatic stage medullary thyroid carcinoma2.9E−03EGFR,NTRK2
Cancer, endocrine system disordersLocoregional medullary thyroid carcinoma2.9E−03EGFR,NTRK2
Cancer, endocrine system disordersMetastatic medullary thyroid carcinoma2.9E−03EGFR,NTRK2
Cancer, endocrine system disordersProgressive medullary thyroid cancer2.9E−03EGFR,NTRK2
7 dEndocrine system disordersBenign thyroid disease3.0E−03ALB,DIO1,GC
Developmental disorder, endocrine system disorders, hereditary disorder, metabolic diseaseDysalbuminemic hyperthyroxinemia4.0E−03ALB
Endocrine system disorders, metabolic diseaseHyperthyroidism6.1E−03DIO1,GC
Amino acid metabolism, molecular transport, small-molecule biochemistryTransport of l-triiodothyronine8.1E−03Slco1a4
Amino acid metabolism, drug metabolism, molecular transport, small-molecule biochemistryTransport of levothyroxine1.2E−02Slco1a4
Amino acid metabolism, molecular transport, small-molecule biochemistryEfflux of l-triiodothyronine1.6E−02ALB
Amino acid metabolism, drug metabolism, molecular transport, small-molecule biochemistryEfflux of levothyroxine1.6E−02ALB
Small-molecule biochemistryInactivation of TH1.6E−02DIO1
Endocrine system development and function, organ developmentActivation of parathyroid gland2.0E−02GC
Endocrine system development and function, small-molecule biochemistryMetabolism of TH2.8E−02DIO1
Organ developmentFunction of thyroid gland3.2E−02DIO1

  • ND = not detected.

  • Pathways related to TH-associated diseases and functions were generated with IPA software; analysis was performed using NEXUS Expression output files of significantly regulated transcripts in response to 1.7–1.8 kBq of 211At at respective time points.