TH-Associated Upstream Regulators in Nonthyroid Tissues
| Tissue | Time point | Upstream regulator | Activation z score | P of overlap | Target molecule in dataset |
| Kidney cortex | 1 h | TH | NA | 5.5E−05 | AK4,G6PC,ME1,PCK1,PER1,UCP1 |
| L-triiodothyronine | 1.7 | 1.5E−04 | G6PC,IGFBP4,Mup1 (includes others), COA4,PCK1,UCP1 | ||
| TH receptor | NA | 4.1E−02 | UCP1 | ||
| 6 h | TH | NA | 5.0E−04 | ACSL5,G6PC,PCK1,PER1 | |
| L-triiodothyronine | 1.2 | 9.7E−04 | G6PC,HBA1/HBA2,PCK1,PDK4 | ||
| 24 h | L-triiodothyronine | 1.4 | 2.7E−05 | ACTB,ADIPOQ,ATP2A2,C4A/C4B,FGA,Kap, LYZ,SCD | |
| TH | −0.15 | 3.4E−03 | Apoc1,APOE,ATP2A2,Cdkn1c,Tmsb4x (includes others) | ||
| Triiodothyronine, reverse | NA | 2.1E−02 | EGR1 | ||
| 7 d | L-triiodothyronine | −0.48 | 1.2E−09 | ADIPOQ,C4A/C4B,G6PC,HP,Kap,Mup1 (includes others), PYGL,SCD,TF,THRSP,UCP1 | |
| Kidney medulla | 1 h | ND | |||
| 6 h | ND | ||||
| 24 h | ND | ||||
| 7 d | TH | NA | 9.0E−03 | Apoc1 | |
| Liver | 1 h | L-triiodothyronine | 1.1 | 1.0E−09 | ABCD2,ACTB,ALB,APOA5,ATP2A2,C1S,CYP17A1,CYP7A1,G6PC,IGFBP1,LYZ,Mup1 (includes others), PCK1,POR,RGN,THRSP |
| TH | 1.1 | 3.2E−06 | ATP2A2,Cyp4a14,CYP7A1,DDC,G6PC,HSP9,AB1,LPL, PCK1,PER1,PML,THRSP | ||
| TH receptor | NA | 5.9E−03 | ABCD2,POR | ||
| Triiodothyronine, reverse | NA | 3.9E−02 | EGR1 | ||
| 6 h | L-triiodothyronine | 1.3 | 1.4E−06 | ADIPOQ,CYP17A1,CYP7A1,G6PC,IGFBP1, Mup1 (includes others), PCK1,POR,THRSP | |
| TH | NA | 3.6E−06 | ALDOB,Cyp4a14,CYP7A1,DDC,G6PC,PCK1, PER1,THRSP | ||
| Triiodothyronine, reverse | NA | 1.9E−02 | EGR1 | ||
| 24 h | L-triiodothyronine | −0.56 | 3.3E−05 | DIO1,ENPP2,FGF21,HP,IGFBP1,Mup1 (includes others), SREBF1,THRSP | |
| TH | NA | 3.8E−03 | IGFBP2,LPL,NTRK2,NUDT7,THRSP | ||
| Triiodothyronine, reverse | NA | 2.1E−02 | EGR1 | ||
| 7 d | L-triiodothyronine | −1.0 | 2.7E−08 | ACTB,ALB,CYP17A1,CYP4A11,CYP7A1,DIO1,G6PC,LYZ,Mup1 (includes others) | |
| TH | NA | 2.7E−03 | Cyp4a14,CYP7A1,G6PC,PER1 | ||
| Triiodothyronine, reverse | NA | 1.2E−02 | EGR1 | ||
| Lungs | 1 h | Triiodothyronine, reverse | NA | 9.8E−03 | EGR1 |
| 6 h | ND | ||||
| 24 h | TH | NA | 7.7E−03 | LPL,ME1,MYH6,THRSP | |
| L-triiodothyronine | 0.042 | 1.4E−02 | ACTB,ADIPOQ,MYH6,THRSP | ||
| Triiodothyronine, reverse | NA | 1.6E−02 | EGR1 | ||
| 7 d | ND | ||||
| Spleen | 1 h | L-triiodothyronine | NA | 2.7E−02 | HP,PDK4,PYGL |
| 6 h | ND | ||||
| 24 h | ND | ||||
| 7 d | ND |
NA = not available; ND = not detected.
Upstream regulators were generated with IPA software; analysis was performed using NEXUS Expression output files of significantly regulated transcripts in response to 1.7–1.8 kBq of 211At at respective time points.