TABLE 5

Postchemotherapy Factors Associated with Pathologic Response to NAC: Univariate and Multivariate Regression, Adjusted for Baseline Variables

Response
FactorUnivariate OR (95% CI)PMultivariate OR (95% CI)P
Chemotherapy
 Regimen
  DualRefRefRefRef
  Triple4.30 (2.16–8.55)3.23 × 10−517.6 (4.39–70.1)5.00 × 10−5
Log time to restaging25.1 (1.10–574)0.0440.32 (0.00–69.2)0.678
Log time to surgery2.28 (0.57–9.07)0.2410.52 (0.06–4.82)0.567
PET/CT variables
 PET scanner
  1RefRefRefRef
  21.09 (0.58–2.07)0.7820.10 (0.02–0.55)0.008
 Restaging PET scanner
  1RefRefRefRef
  21.30 (0.66–2.57)0.4465.24 (0.95–28.9)0.057
 Restaging mN stage
  0 (0 avid nodes)RefRefRefRef
  1 (1–2 avid nodes)0.16 (0.02–1.28)0.0841.07 (0.07–16.8)0.959
  2 (>2 avid nodes)0.16 (0.02–1.28)0.0842.39 (0.18–31.6)0.509
  Restaging log SUVmax2.37 × 10−3 (4.21 × 10−4 to 0.01)6.93 × 10−123.84 × 10−4 (1.17 × 10–5 to 0.02)9.89 × 10−6
  Restaging log avid length0.61 (0.51–0.73)3.80 × 10−81.01 (0.76–1.34)0.951
  Restaging log MTL0.03 (0.01–0.10)3.88 × 10−100.02 (4.03 × 10−3 to 0.06)6.19 × 10−9
Subset of patients with 18F-FDG–avid nodes (n = 30)
 Log nodal SUVmax8.71 (0.01–5787)0.514NANA
Subset of patients staged using second PET/CT scanner (n = 155)
 Log SUVmean1.58 × 10−4 (7.51 × 10−6 to 3.23 × 10−3)1.78 × 10−41.13 × 10−7 (8.55 × 10−12 to 1.46 × 10−3)9.32 × 10−5
 SUVpeak5.05 × 10−3 (1.81 × 10−4 to 0.14)1.85 × 10−30.57 (0.39–0.84)3.90 × 10−3
 Log MTV0.28 (0.18–0.44)0.2030.09 (0.03–0.28)2.03 × 10−5
 Log TGVmax0.32 (0.21–0.48)3.91 × 10−80.11 (0.04–0.31)2.72 × 10−5
 Log TGVmean0.30 (0.19–0.46)3.27 × 10−80.10 (0.03–0.29)2.29 × 10−5

  • CI = confidence interval; Ref = reference; MTL = metabolic tumor length; NA = not applicable.