Group Comparison Results of Clinical Variables and 11C-DTBZ PET Variables in Group of Patients (n = 17) with Either Normal or Partial, Mild Cardiac Denervation (Global SEP ≥ 100) Versus Group of Patients (n = 22) with More Extensive Cardiac Denervation (Global SEP ≤ 150)
| Variable | Normal or relatively preserved sympathic cardiac innervation (n = 17) | More extensive sympathetic cardiac denervation (n = 22) | Student t test |
| Age | 63.7 ± 5.8 | 61.0 ± 5.9 | 1.3994 (P = 0.0850) |
| MoCa score | 25.63 ± 1.69 | 26.84 ± 1.92 | 1.55 (P = 0.14) |
| Duration of motor disease (y) | 4.3 ± 3.2 | 5.1 ± 3.1 | −0.8347 (P = 0.2046) |
| Hoehn and Yahr stage | 2.23 ± 0.32 | 2.18 ± 0.42 | 0.3776 (P = 0.3541) |
| Nonmotor experiences of daily living | 5.24 ± 4.42 | 6.54 ± 5.51 | −0.8005 (P = 0.7857) |
| UPDRS scores | |||
| Motor UPDRS scores | 27.74 ± 7.30 | 28.86 ± 13.412 | −0.3122 (P = 0.6217) |
| UPDRS tremor scores | 4.13 ± 43.10 | 3.39 ± 2.71 | 0.7410 (P = 0.2321) |
| UPDRS PIGD scores | 5.43 ± 3.06 | 6.08 ± 3.21 | −0.5943 (P = 0.7218) |
| Fatigue severity scale | 22.75 ± 12.86 | 32.16 ± 13.18 | 1.71 (P = 0.10) |
| Epworth sleepiness scale | 6.35 ± 2.78 | 8.29 ± 4.27 | −1.6088 (P = 0.0582) |
| Striatal 11C-DTBZ DVR | 2.04 ± 0.27 | 1.91 ± 0.30 | 1.3043 (P = 0.1002) |
| Putamen 11C-DTBZ DVR | 1.90 ± 0.25 | 1.78 ± 0.30 | 1.3764 (P = 0.0886) |
| Caudate nucleus 11C-DTBZ DVR | 2.00 ± 0.33 | 1.88 ± 0.33 | 1.0882 (P = 0.1419) |
MoCa = Montreal Cognitive Assessment; UPDRS = Unified Parkinson Disease Rating Scale; PIGD = postural instability and gait difficulties; DVR = distribution volume ratio.
Data in parentheses are significance levels.