TABLE 1

Estimated Radiation-Absorbed Doses to Adult Human After Intravenous Injection of ⁸⁹Zr-Df-Pembrolizumab in PBL and NSG Mice (n = 4)

	PBL model (NSG mice with human PBMCs)				NSG mice
Organ	mGy/MBq	SD	rad/mCi	SD	mGy/MBq	SD	rad/mCi	SD
Adrenals	0.028	0.001	0.104	0.001	0.028	0.001	0.105	0.001
Brain	0.249	0.005	0.919	0.019	0.245	0.006	0.905	0.022
Breasts	0.185	0.001	0.683	0.005	0.185	0.002	0.684	0.008
Small intestine	0.025	0.001	0.091	0.001	0.025	0.001	0.091	0.001
Stomach wall	0.630	0.004	2.329	0.014	0.630	0.005	2.332	0.019
Kidneys	0.030	0.001	0.113	0.005	0.035	0.001	0.128	0.005
Liver	1.207	0.022	4.465	0.083	1.196	0.061	4.426	0.225
Lungs	0.556	0.004	2.059	0.016	0.562	0.003	2.078	0.010
Muscle	0.019	0.001	0.070	0.002	0.019	0.001	0.072	0.001
Ovaries	1.591	0.006	5.885	0.023	1.594	0.013	5.897	0.046
Pancreas	0.029	0.001	0.108	0.001	0.029	0.001	0.108	0.002
Red marrow	0.533	0.003	1.970	0.010	0.533	0.004	1.972	0.014
Skin	0.373	0.002	1.380	0.008	0.373	0.003	1.378	0.012
Spleen	0.030	0.001	0.112	0.002	0.028	0.007	0.104	0.027
Thymus	0.024	0.001	0.087	0.101	0.024	0.013	0.089	0.048
Salivary glands	1.246	0.082	4.609	0.013	0.838	0.004	3.099	0.014
Urinary bladder wall	0.573	0.004	2.118	0.001	0.574	0.001	2.125	0.002
Uterus	0.026	0.001	0.097	0.001	0.026	0.001	0.097	0.001
Total-body effective dose (mSv/MBq)	0.597	0.005			0.581	0.003