Analytic and Affinity Data of GRPr Antagonists
| Mass ([M+2H]+) | |||
| Compound | Calculated | Measured | IC50 (nmol/L) |
| Ga-DOTA-AR | 906.4 | 906.5 | 0.48 ± 0.18 (5) |
| Ga-HZ219 | 971.0 | 970.9 | 0.69 ± 0.18 (4) |
| Ga-HZ220 | 1430.5 | 1430.4 | 21.4 ± 7.4 (6) |
| DOTA-RM2 | 853.4 | 853.7 | 7.7 ± 3.3 |
Values (mean ± SD) from binding studies were determined in PC-3 cells. Number of independent experiments is given in parentheses (triplicate measurements were performed in each experiment). Data for DOTA-RM2 are from Mansi et al. (15).