Biodistribution of 68Ga-Labeled HZ220, DOTA-AR, and DOTA-RM2 in PC-3 Xenografts After PET Imaging
| 68Ga-HZ220 | ||||
| Organ | 1 h (n = 7) | 1 h, blocked (n = 5) | 68Ga-DOTA-RM2, 1 h (n = 3) | 68Ga-DOTA-AR, 1 h (n = 3) |
| PC-3 | 5.50 ± 1.03 | 1.20 ± 0.30 | 9.14 ± 0.49 | 4.53 ± 1.11 |
| Blood | 0.78 ± 0.62 | 0.93 ± 0.31 | 0.20 ± 0.03 | 0.24 ± 0.06 |
| Muscle | 0.15 ± 0.06 | 0.25 ± 0.14 | 0.05 ± 0.01 | 0.19 ± 0.24 |
| Heart | 0.28 ± 0.10 | 0.43 ± 0.17 | 0.09 ± 0.01 | 0.11 ± 0.01 |
| Lung | 1.93 ± 1.56 | 1.85 ± 0.51 | 0.19 ± 0.08 | 0.61 ± 0.21 |
| Liver | 1.03 ± 0.42 | 1.35 ± 0.46 | 0.27 ± 0.02 | 0.81 ± 0.16 |
| Pancreas | 2.70 ± 1.51 | 0.69 ± 0.22 | 8.67 ± 3.01 | 3.76 ± 0.66 |
| Spleen | 0.49 ± 0.46 | 0.46 ± 0.14 | 0.45 ± 0.26 | 0.19 ± 0.05 |
| Stomach | 0.46 ± 0.22 | 0.44 ± 0.18 | 1.01 ± 0.07 | 0.61 ± 0.15 |
| Small intestine | 0.50 ± 0.28 | 0.48 ± 0.21 | 0.87 ± 0.23 | 0.89 ± 0.65 |
| Large intestine | 0.29 ± 0.08 | 0.29 ± 0.13 | 0.81 ± 0.09 | 0.35 ± 0.07 |
| Bone | 0.34 ± 0.24 | 0.35 ± 0.15 | 0.12 ± 0.03 | 0.23 ± 0.19 |
| Kidney | 16.9 ± 6.5 | 20.1 ± 6.1 | 5.01 ± 2.29 | 4.58 ± 1.63 |
| Brain | 0.03 ± 0.01 | 0.04 ± 0.01 | 0.03 ± 0.01 | 0.03 ± 0.02 |
| Tumor-to-organ ratios | ||||
| PC-3 to blood | 9.0 ± 2.9 | 1.4 ± 0.6 | 33 ± 22 | 20 ± 10 |
| PC-3 to muscle | 40 ± 11 | 6.4 ± 4.4 | 211 ± 47 | 103 ± 63 |
| PC-3 to pancreas | 3.0 ± 2.7 | 1.9 ± 0.8 | 1.2 ± 0.5 | 1.2 ± 0.3 |
| PC-3 to kidney | 0.4 ± 0.1 | 0.1 ± 0.0 | 2.1 ± 0.8 | 1.1 ± 0.5 |