Mean activity per cycle | | | | |
≤5.5 GBq | 40 | 20 (50%) | 1 (reference) | |
>5.5 GBq | 59 | 25 (42%) | 0.725 (0.328–1.647) | 0.46 |
Previous chemotherapy | | | | |
Yes | 55 | 21 (38%) | 1 (reference) | |
No | 44 | 24 (55%) | 1.94 (0.869–5.33) | 0.11 |
Visceral metastases | | | | |
Yes | 29 | 7 (24%) | 1 (reference) | |
No | 70 | 38 (54%) | 3.732 (1.412–9.864) | <0.01 |
Bone metastases | | | | |
No | 13 | 6 (46%) | 1 (reference) | |
Yes | 86 | 39 (45%) | 0.968 (0.3–3.21) | 0.96 |
Lymph node metastases | | | | |
No | 77 | 34 (44%) | 1 (reference) | |
Yes | 22 | 11 (50%) | 0.791 (0.306–2.043) | 0.63 |
Alkaline phosphatase* | | | | |
<220 U/L | 72 | 39 (54%) | 1 (reference) | |
≥220 U/L | 25 | 5 (20%) | 0.21 (0.072–0.625) | <0.01 |
Cumulative activity after 2 cycles† | | | | |
≤11.8 GBq | 32 | 16 (50%) | 1 (reference) | |
>11.8 GBq | 29 | 19 (66%) | 1.9 (0.676–5.366) | 0.22 |
Cumulative activity after 3 cycles | | | | |
≤17.4 GBq | 8 | 6 (75%) | 1 (reference) | |
>17.4 GBq | 12 | 8 (67%) | 0.667 (0.09–4.928) | 0.69 |
No. of cycles | | | | |
1 | 28 | 8 (29%) | 1 (reference) | |
2 | 36 | 18 (50%) | 2.5 (0.87–7.13) | 0.94 |
3 and 4 | 20 | 14 (70%) | 5.83 (1.65–20.559) | 0.02 |