Summary of In Vitro Studies of Each 18F-Labeled Compound
| Compound | Ki (nM)* | Retention time (min)† | log D‡ |
| 18F-8a | 3.35 | 16.6 | −2.47 |
| 18F-8b | 8.69 | 21.4 | −2.13 |
| 18F-10a | 2.23 | 15.4 | −2.69 |
| 18F-10b | 17.6 | 18.6 | −2.21 |
| 125I-IGLCE | 4.97 | ND | −1.97 |
| 18F-DCFPyL | 15.5 | ND | −3.81 |
| 2-PMPA¶ | 31.2 | ND | ND |
↵* Values represent mean data of 3 independent assays. Binding inhibition assays were performed using each unlabeled compound and 125I-DCIT.
↵† Retention time in reversed-phase HPLC analysis.
↵‡ Distribution coefficient; values represent mean of 5 samples.
↵¶ PSMA inhibitor 2-(phosphonomethyl)pentanedioic acid was used in inhibition assay as positive control.
ND = not determined.