Objective, Study Design, and Analysis of Preanalytic Study
| Preanalytic study | Objective | Design | Assessment |
| Patient studies: repeated bone scans in patients with skeletal metastasis | Effect on BSI reproducibility | Grp1, repeated scan with same scanning speed and same camera as that of the first bone scan | Absolute value of the difference between the observed automated BSI values of the repeated bone scans |
| Grp2, repeated scan with double (2×) scanning speed as that of the first bone scan | |||
| Grp3, repeated scan with a γ-camera different from that of the first scan | |||
| Simulation studies: phantoms with predefined tumor burden (phantom-BSI) | Effect on BSI accuracy | Simulation with variable image counts | Absolute value of the difference between the observed automated BSI and the phantom-BSI |
| Simulation with different γ-cameras |