Currently Available Functional-Imaging Techniques for GEP NET Investigation
| Characteristic | 111In-pentetreotide SPECT/CT | 123I-MIBG SPECT/CT | 68Ga-SSA PET/CT | 18F-FDOPA PET/CT | 18F-FDG PET/CT |
| Use | Primary staging; restaging; patient selection before PRRT | Patient selection before 131I-MIBG radiometabolic treatment | Primary staging; restaging; patient selection before PRRT; imaging when primary site is unknown | Primary staging; imaging when primary site is unknown (based on presumption of ileal origin); (restaging?) | Prognostic stratification; imaging of high-grade G2/G3 NETs |
| Spatial resolution | Low (>10 mm) | Low (>10 mm) | High (5 mm) | High (5 mm) | High (5 mm) |
| Procedure length | 2 d | 2 d | 1 d | 1 d | 1 d |
| Radiation exposure | Moderate | Mild | Mild | Mild | Mild |
| Other | Is approved for NET imaging | Has low sensitivity for GEP NETs | Will soon replace conventional SSTR scintigraphy | May be less sensitive than 68Ga-SSA PET/CT for nonileal GEP NETs | Is widely available |