Proportions of 18F-FPyKYNE-Losartan and Its Hydrophilic-Labeled Metabolites in Pig Plasma in Normal and Blocking Conditions
| Time point (min) | ||||||||
| Condition | Identity | 0 | 1 | 2 | 5 | 10 | 20 | 40 |
| Baseline | Hydrophilic metabolite (%) | 0 ± 0 | 0 ± 0 | 0 ± 0 | 32 ± 6 | 83 ± 2 | 94 ± 4 | 100 ± 0 |
| Unchanged tracer (%) | 100 ± 0 | 100 ± 0 | 100 ± 0 | 68 ± 6 | 17 ± 2 | 6 ± 4 | 0 ± 0 | |
| Blocking | Hydrophilic metabolite (%) | 0 ± 0 | 0 ± 0 | 3 ± 13 | 68 ± 21 | 96 ± 0 | 99 ± 3 | 100 ± 0 |
| Unchanged tracer (%) | 100 ± 0 | 100 ± 0 | 97 ± 12 | 32 ± 15* | 4 ± 1* | 1 ± 2* | 0 ± 0 | |
↵* P < 0.05 compared with baseline.
n = 3 per time point.