TABLE 1

Proportions of Unchanged ¹⁸F-FPyKYNE-Losartan and Its Labeled Metabolites in Rat Kidney Homogenate at Respective Time Points

				10 min^*
Peak	Identity	0 min	5 min	0 mg/kg	5 mg/kg	10 mg/kg	20 min	30 min
1	Hydrophilic metabolite	0 ± 0	5 ± 4	12 ± 1	76 ± 20	88 ± 15^†^‡	17 ± 8	39 ± 20
2	Hydrophobic metabolite	0 ± 0	2 ± 1	4 ± 2	2 ± 2^†	2 ± 0^†	5 ± 2	3 ± 2
3	Unchanged tracer	100 ± 0	93 ± 4	84 ± 2	22 ± 20^†	10 ± 14^†	78 ± 10	58 ± 19

↵* Data are given for 3 different candesartan blocking doses.
↵† P < 0.05, compared with baseline.
↵‡ Compared with previous dose.