18F-Fluciclovine Activity Correlated to Demographic, Histologic, and Immunohistochemical Characteristics
| 18F-Fluciclovine uptake (SUVmax) (min) | ||||||||||
| Subject no. | Age (y) | Location of breast lesion | Size (cm) | TNM | Histologic diagnosis | Ki-67 (%) | 5 | 17 | 29 | 41 |
| 1 | 63 | RUO | 1.5 × 1.2 × 1.0 | T1cNxM0 | IDC NG2; ER+/PR+/HER2− | High (21) | 5.6 | 5.1 | 4.8 | 3.6 |
| RUI | Diffuse | NA | Stable posttherapy scar* | NA | 1.2 | 1.4 | 1.5 | 1.4 | ||
| 2 | 50 | RUI | 2.5 × 2.0 × 0.3 | NA | Ductal hyperplasia and columnar cells with microcalcifications | NA | 2.0 | 1.8 | 1.8 | 1.5 |
| 3 | 67 | LUI | 1.1 × 1 | T1N0M0 | IDC NG1; ER+/PR+HER2− | High (29) | 9.7 | 7.4 | 6.6 | 6.1 |
| 4 | 77 | RUO | 2.0 | T1cN1aM0 | IDC NG2; ER+/PR−/HER2+ | Intermediate (11) | 3.0 | 3.8 | 4.0 | 4.2 |
| RUO | 0.7 | NA | Fibroadipose tissue | NA | 0.6 | 0.6 | 0.5 | 0.3 | ||
| 5 | 60 | RLO | 1.4 × 1.2 × 1.5 | T1N0M0 | ILC NG2; ER+/PR+/HER2− | High (45) | 3.9 | 3.3 | 3.4 | 3.5 |
| LUI | 3.2 × 1.5 × 1.9 | T2N1M1 | IDC NG3; ER+/PR−/HER2− | High (97) | 7.9 | 8.3 | 8.2 | 8.2 | ||
| 6 | 54 | RUI | 15.1 × 14.7 × 15.2 | T4cN1M0 | IMC; ER−/PR−/HER2− | High (62) | 8.6 | 8.9 | 8.9 | 9.1 |
| Left subareaolar | 1.8 | NA | Fibrocystic change, apocrine metaplasia, and focal ductal hyperplasia | NA | 1.2 | 1.1 | 1.1 | 1.2 | ||
| 7 | 60 | LLI | 2.0 × 1.5 × 1.4 | T1cN0M0 | IDC NG3; ER+/PR−/HER2− | High (95) | 7.5 | 6.2 | 5.4 | 5.0 |
| 8 | 89 | LUO | 3.0 × 2.8 × 2.1 | T2N0M0 | IDC NG3; ER+/PR+/HER2− | High (40) | 8.8 | 9.3 | 9.3 | 9.3 |
| Right axillary tail | 2.3 × 2.2 × 1.9 | T2N0M0 | IDC NG3; ER−/PR−/HER2− | High (34) | 11.7 | 12.3 | 10.3 | 11.0 | ||
| 9 | 68 | LUO | 15.4 | T3NxM0 | ILC NG2; ER+/PR+/HER2− | High (39) | 6.6 | 6.4 | 5.9 | 5.5 |
| 10 | 54 | RUO | 1.5 | T1N1M0 | ILC NG1; ER+/PR−/HER2− | High (15) | 2.2 | 2.0 | 1.7 | 1.8 |
| 11 | 73 | LUO | 4 × 3.2 × 1.3 | T2N0M0 | ILC NG1; ER+/PR+/HER2− | Low (2) | 2.6 | 3.2 | 3.4 | 3.6 |
| 12 | 49 | LUO | 5.5 × 4.6 | T3N2aM0 | ILC NG2; ER+/PR+/HER2− | High (25) | 3.5 | 4.5 | 4.5 | 4.9 |
*Confirmed on conventional imaging.
RUO = right upper outer; NG = Nottingham grade; RUI = right upper inner; NA = not applicable; LLI = left lower inner; RLO = right lower outer; LUI = left upper inner; LUO = left upper outer.