TABLE 1

B_max and K_d Values for ³H-AV-1451 and ³H-MK-6240 Binding in NFT-rich AD Brain Tissues

	³H-AV-1451				³H-MK-6240
Donor tissue	B_max (nM)	K_d (nM)	B_max/K_d	% NDB at K_d	B_max (nM)	K_d (nM)	B_max/K_d	% NDB at K_d
AD507 entorhinal cortex	15.0	1.4	11	88	7.8	0.14	56	33
AD906 entorhinal cortex	62.5	3.72	17	78	18.8	0.30	63	30
AD111 frontal cortex	67.0	1.70	39	68	35.9	0.25	144	19
AD790 frontal cortex	46.9	0.63	74	55	39.3	0.24	164	24
AD106 frontal cortex	119.7	1.10	109	36	93.4	0.38	246	12

NDB was defined by T808.