TABLE 2

Patient Demographics and HER2 Expression Results

Patient no.Age (y)Metastatic sites at enrollmentConfirmatory HER2 IHC of primary breast cancerSuggestive foci on 89Zr-trastuzumab PET/CT?Image-guided biopsy results
146Bone, liver0None
241Nodes1+Nodes (SUVmax, 4.6)IHC, 3+
358Bone, liver, nodes0Bone (SUVmax,7.1)IHC, 1+
469Bone, liver, nodes0None
538Bone, liver, nodes1+Bone (SUVmax, 5.9)IHC, 2+; FISH, failure; MSK-IMPACT, amplified
642Nodes, adrenal1+Adrenal (SUVmax, 9.2)IHC, 2+; FISH, 1.4
783Bone, liver, nodes, lung1+Bone (SUVmax, 9.7)IHC, 1+
854Bone, liver, nodes, lung0None
948Bone, liver, nodes, pleura1+None
  • IHC = immunohistochemistry score.

  • All 9 women had primary invasive ductal breast cancer.