TABLE 3

Brain Regions with Significant Metabolic Changes Before and After hRPE Cell Implantation in Parkinsonian Macaques

	Metabolic increase^* (MPTP > normal)					Metabolic decrease^† (implant < MPTP)
Brain region	X	Y	Z	Z_max	Size (mm³)	X	Y	Z	Z_max	Size (mm³)
Medial frontal/cingulate	8	6	28	3.3	376	4	6	36	2.9	208
Insula/SMC/putamen	30	16	18	4.9	1304	26	8	18	3.0	744
Frontal/SMA	28	24	18	4.5		26	26	16	3.4	160
Thalamus	6	14	8	2.9	1872	6	14	6	2.8	320
Pons	4	0	−14	3.9		4	0	−14	3.3	184

↵* Unpaired t test: P < 0.005 uncorrected and survived at false-discovery rate–corrected P < 0.05.
↵† Paired t test: P < 0.005 uncorrected and did not survive at false-discovery rate–corrected P < 0.05.
SMC = sensorimotor cortex; SMA = supplementary motor area.