Test–Retest Variability of 18F-PF-05270430 Binding Parameters in Rhesus Monkeys
| % difference between test and retest scan | ||||||
| BPND | ||||||
| VT (MA1) | MA1 | SRTM | ||||
| Region | Mean | SD | Mean | SD | Mean | SD |
| Cerebellum | 4 | 2 | — | — | — | — |
| Occipital cortex | 4 | 2 | 61 | 17 | 47* | —* |
| Temporal cortex | 1 | 1 | 25 | 5 | 26 | 6 |
| Cingulate cortex | 2 | 2 | 9 | 6 | 8 | 11 |
| Frontal cortex | 6 | 6 | 24 | 19 | 24 | 24 |
| Caudate | 4 | 4 | 11 | 6 | 11 | 9 |
| Putamen | 4 | 3 | 10 | 5 | 10 | 5 |
| Nucleus accumbens | 7 | 7 | 18 | 7 | 19 | 9 |
| High-binding region | 4 | 6 | 13 | 6 | 13 | 7 |
↵* Test–retest variability of BPND (SRTM) in occipital cortex calculated from one subject (BM090), because estimates from subject TM762 were unstable (relative SE > 100%).
Percentage difference in VT and BPND estimated from MA1 and SRTM analysis averaged across two subjects. High binding regions: putamen, caudate, and nucleus accumbens.