Organ | [Nle14,Lys40(Ahx-DOTA-68Ga)NH2]Ex-4 | [Nle14,Lys40(Ahx-DOTA-68Ga)NH2]Ex-4 block* | [Lys27(Ahx-DOTA-68Ga)]Ex(9-39)NH2 | [Lys27(NODAGA-68Ga)]Ex(9-39)NH2 | [Lys40(NODAGA-68Ga)NH2]Ex(9-39) |
Blood | 0.4 ± 0.1 | 0.4 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.0 | 0.3 ± 0.0 |
Heart | 0.2 ± 0.0 | 0.1 ± 0.1 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 |
Lung | 5.0 ± 0.9 | 0.9 ± 0.3 | 0.0 ± 0.0 | 1.3 ± 0.4 | 1.4 ± 0.4 |
Spleen | 0.4 ± 0.1 | 0.5 ± 0.2 | 0.1 ± 0.1 | 0.25 ± 0.04 | 0.4 ± 0.2 |
Liver | 1.1 ± 0.1 | 0.9 ± 0.2 | 0.0 ± 0.1 | 0.6 ± 0.2 | 0.6 ± 0.2 |
Pancreas | 12.5 ± 2.2 | 0.4 ± 0.1 | 0.1 ± 0.0 | 0.5 ± 0.1 | 1.0 ± 0.1 |
Stomach | 2.8 ± 0.3 | 0.4 ± 0.1 | 0.2 ± 0.0 | 0.5 ± 0.2 | 0.7 ± 0.3 |
Intestine | 1.8 ± 0.4 | 0.4 ± 0.1 | 0.3 ± 0.1 | 0.5 ± 0.2 | 0.3 ± 0.1 |
Kidney | 235.8 ± 17.0 | 277.3 ± 13.9 | 113.8 ± 23.8 | 101.0 ± 21.0 | 78.4 ± 8.5 |
Adrenal | 6.5 ± 1.4 | 4.7 ± 1.4 | 2.0 ± 0.5 | 5.0 ± 1.9 | 6.0 ± 4.5 |
Muscle | 0.3 ± 0.1 | 0.3 ± 0.1 | 1.0 ± 0.4 | 0.3 ± 0.1 | 0.3 ± 0.2 |
Bone | 0.6 ± 0.2 | 0.5 ± 0.2 | 0.6 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.0 |
Ins-1E | 40.2 ± 8.2 | 1.4 ± 0.1 | ND | 0.7 ± 0.2 | 2.2 ± 0.2 |
↵* 80 nmol of Ex(9-39) were preinjected 5 min before tracer.
ND = not determined.
Data are mean ± SD %IA/g, n = 3–4.