Organ | 1 h | 1-h Irenat* | 1-h block† | 4 h | 24 h |
Blood | 2.41 ± 0.52 | 2.33 ± 0.39 | 2.75 ± 0.03 | 0.82 ± 0.02 | 0.02 ± 0.01 |
Heart | 1.11 ± 0.20 | 1.03 ± 0.19 | 0.69 ± 0.02 | 0.44 ± 0.09 | 0.01 ± 0.00 |
Lung | 19.94 ± 2.60 | 31.87 ± 2.92 | 1.49 ± 0.34 | 11.85 ± 1.76 | 0.14 ± 0.06 |
Spleen | 0.97 ± 0.12 | 0.78 ± 0.14 | 0.66 ± 0.08 | 0.29 ± 0.05 | 0.02 ± 0.01 |
Liver | 27.95 ± 3.20 | 25.03 ± 1.39 | 25.32 ± 2.82 | 9.30 ± 1.30 | 0.13 ± 0.01 |
Pancreas | 28.85 ± 5.10 | 27.47 ± 9.29 | 0.72 ± 0.03 | 10.16 ± 2.50 | 0.16 ± 0.09 |
Stomach | 7.32 ± 2.66 | 8.12 ± 3.60 | 1.10 ± 0.20 | 2.79 ± 0.21 | 0.07 ± 0.05 |
Intestine | 3.67 ± 0.68 | 3.94 ± 1.05 | 3.24 ± 2.09 | 1.43 ± 0.13 | 0.05 ± 0.02 |
Kidney | 12.12 ± 1.41 | 13.53 ± 2.71 | 22.06 ± 1.60 | 4.15 ± 0.70 | 0.14 ± 0.04 |
Adrenals | 0.84 ± 0.38 | 0.74 ± 0.00 | 1.04 ± 0.01 | 0.32 ± 0.16 | ND |
Muscle | 0.22 ± 0.04 | 0.21 ± 0.04 | 0.22 ± 0.02 | 0.12 ± 0.05 | 0.01 ± 0.00 |
Bone | 0.31 ± 0.05 | 0.27 | 0.36 ± 0.03 | 0.15 ± 0.06 | 0.02 ± 0.02 |
Ins-1E | 42.46 ± 8.05 | 40.53 ± 8.19 | 2.78 ± 0.22 | 19.76 ± 4.26 | 0.69 ± 0.25 |
Thyroid‡ | 2.45 ± 0.56 | 0.42 ± 0.08 |
↵* To block sodium iodide symporter, irenat (120 mg/kg) was injected intravenously before tracer injection.
↵† 80 nmol of Ex(9-39) were injected before tracer.
↵‡ Thyroid was removed together with trachea, and total mass (∼60 mg) was used to calculate %IA/g (actual mass of thyroid is several mg).
ND = not detected.
Data are mean ± SD %IA/g, n = 3.