TABLE 1

Overview of Resin and Glass 90Y Radioembolization Products

CharacteristicSIR-SpheresTheraSphere
CompositionResin with 90Y bound to surfaceGlass permanently impregnated with 90Y
Size32.5 ± 5 μm20–30 μm
Number of spheres per vial40–80 million1.2–8 million
Specific activity at calibration50 Bq/sphere2500 Bq/sphere
Time after infusion when 90% of absorbed dose is delivered∼9 d∼9 d
Shelf life from time of calibration24 h12 d
Specific activity at treatment50–38.6* Bq/sphere2,500–111* Bq/sphere
Range of microsphere-number density per gray of average tumor-absorbed dose413–535 mL-Gy−18.2–186 mL-Gy−1
Range of microsphere-number density at…
 100-Gy average tumor-absorbed dose41,300–53,500 mL−1820–18,600 mL−1
 250-Gy average tumor-absorbed dose103,250–133,750 mL−12,050–46,500 mL−1
  • * Based on decay at expiration/shelf-life of product.

  • Based on clinical specific activity range.

  • Adapted from Salem and Thurston (4).